N-asetilsistein ve ozon gibi antioksidan ilaçların staz zonu üzerindeki etkinliği

Title: The effectiveness of antioxidant drugs such as N-acetylcysteine and Ozone on the stasis zone. Short title: Effectiveness Purpose: Stasis zone, zone around coagulation is important for prevention necrosis in burns. Various were studied literature to prevent previous researches have shown Nacetylcysteine treatment both remote organs local side thermal injury. Demonstration N acetylcysteine injury was goal this study. Methods: For purpose, 24 4-month-old Wistar albino type female rats weighing 200±20 g used Compound burning model made these rats. Next, compound applied combustion compare Ozone. To identfy histopathological destruction severity a scoring method applied. Malondialdhyede (MDA), Glutathione Peroxidase (GPx), Superoksid dismutase (SOD), catalase (CAT) levels analyzed serum samples find out alterations balance between oxidatitaion antioxidation system. Results: While highest MDA observed group I, decrease significant II III (p=0.03 p<0.02). SOD significantly higher compared (p<0.05). CAT than I (p<0.001, p<0.001). GPx (p<0.001), (p<0.001). Histopathological scores lower (p=0.001). Conclusion: This study showed that are effective agents rescuing site. It also concluded might be more beneficial N-acetylcysteine.